Dalian Institute of Chemical Industry successfully developed catalytic materials that can adsorb and inactivate new coronavirus

Recently, the pneumonia epidemic of the new coronavirus infection has affected the entire world, and it has had a huge impact on normal human activities. There are many types of viruses, and their structure and composition characteristics are similar and relatively clear. However, from a chemical point of view, the proteins, ribonucleic acids, fat membranes and other biological macromolecules contained in the virus are not as stable as ordinary organic molecules and are easy to hydrolyze or oxidize inactivated . Therefore, it is theoretically feasible to achieve the adsorption and inactivation of viruses based on the chemical properties of solid materials such as adsorption performance, acidity and alkalinity, and redox properties.

Under the guidance of this design concept, our institute has successfully developed a catalytic material that can adsorb and inactivate new coronaviruses. The results of virus inactivation experiments conducted by the Anhui Provincial Center for Disease Control and Prevention (hereinafter referred to as "Anhui CDC") show that the material has the function of directly adsorbing and inactivating new coronaviruses, with an inactivation efficiency of 96.5% to 99.9%. In the Anhui CDC experimental environment, the concentration of the new coronavirus is 5 μg / ml, which is much higher than the pathogenic concentration of the virus in real life scenarios. These solid catalytic materials are non-toxic, insoluble in water and organic solvents, can be made into particles or carried on various carriers, and are expected to be widely used in anti-epidemic products and daily air and water purification supplies Adsorption and deactivation to improve the level of protection.

As early as 2003, when the SARS virus raged, our institute put forward the idea of ​​inactivating SARS virus using the principle of adsorption and catalysis, and urgently mobilized the relevant research forces of catalysis, biological analysis and detection, and joined the virus laboratory of Dalian Medical University to form a joint Research team, using cross-disciplinary advantages, carrying out systematic research on material design and synthesis, screening, cytotoxicity and virus inactivation performance; according to the catalyst design concept, quickly synthesized more than 100 inorganic porous solid materials and selected typical samples from them. After verification of several parainfluenza virus inactivation experiments, it was finally sent to the Academy of Military Medical Sciences for SARS virus inactivation experiments, which confirmed that the selected materials had the function of directly adsorbing and inactivating SARS virus. In addition, after detection by Dalian Medical University, this type of material also has a significant inhibitory effect on human adenovirus type Ⅰ, type Ⅴ and human herpes virus type Ⅰ. Relevant work was published in the Journal of Catalysis, Chromatography and China Virology. This is also the earliest domestic and international report on the use of catalytic materials to inactivate SARS virus. Although the study quickly reached the expected target, it was also the time when the SARS epidemic quickly ended, so it did not really play a role in combating the SARS epidemic.

The new coronaviruses that have caused large-scale outbreaks recently belong to the Coronaviridae family and SARS viruses, and the genome sequences of the two have a high degree of similarity. Our institute has keenly restarted the work of 17 years ago, and quickly established a joint cross-disciplinary team in various fields. On the basis of the previous work, we upgraded the technical means to overcome many difficulties, focusing on the batch preparation technology of catalytic materials and the inactivation of material adsorption Research on virus performance and mechanism. At present, the production of single batch of over 100 kg of catalytic materials has been completed, with production capacity above ton level.

The research team also carried out application research on this type of catalytic material based on different scenarios such as air purification and personal protection, and completed the loading and molding technology and process development of carriers such as honeycomb, metal mesh and non-woven fabrics. Lay the foundation in the application of air filtration and purification, masks and other products. At present, the research team is actively looking for cooperative enterprises to jointly develop related products, so as to put them into practical applications as soon as possible, and help China and the world to win the battle of prevention and control of the new coronavirus pneumonia epidemic.

The epidemic prevention and technological breakthrough project has received strong support from the Clinical Research Hospital (Hefei) of the Chinese Academy of Sciences to deal with epidemic prevention and control scientific research headquarters, the Chinese Academy of Sciences, the Chinese Academy of Engineering, and Dalian Medical University. (Text / Ma Lei, Xu Lei, Park Hailong, Chen Weidong, Wang Yongjin / Chen Weidong)

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